Most of the girls i have laid with from daygame have been 1-sets. However, i catch myself opting out in certain situations.
And on it goes. The dumbest one i've heard is to not approach girls with headphones in (next to "only approach girls who give you IOIs/AIs/choosing signals/whatever"). Lol yeah, have fun with that.
Personally i have almost completely stopped approaching girls who's with one or more other people. Idk why, i think i have some unconscious confirmation bias and a lack of conviction, which is pretty sad, and i miss the days of starting out and being open-minded and approaching whatever i found hot, no matter the situation (i would open moms with "I know this is random, but i just thought your little sister here was pretty cute and wanted to meet her" haha).
I guess what i'm trying to say is, when you have laid a few girls from 2-sets in daygame then you cannot tell yourself anymore that it "doesn't work". You can claim that it is low odds and a "waste of time" but in my opinion that depends mostly on you. Since i live in a town of less than 200k people and tend to run into the same girls twice* i tend to A) go for lone girls and B) approach when not too many people are around, doing it more discreet. I play it more "safe". So if i approach a group of 3 girls, i just spent 3 rounds of ammunition in this city, if you know what i mean. When i'm in the capital i have no care in the world how many people are watching, because i have anonymity. That's just me personally.
*fun story not so long ago, i approached a 2-set and then i realized that my target's friend was a girl that looked a bit similiar and then my target told me after my opener "Just like you told all my other friends" ahaha it happens but whatever, i just kept talking like nothing but then she excused herself and they walked off. It's a twisted worldview they have that i'm a "player" who does this quote "all the time" and therefore "no good" but there is no problem in doing hundreds of tinder swipes a week or being fucked by the same guy from their social circle. But that's just the female brain at work lol.